All in WOMEN'S HEALTH

Hyperemesis Gravidarum - Severe Morning Sickness: Are Mitochondria Involved?

Chandler Marrs, PhD

From the research on AFLP, we know that a mutation in the mitochondrial enzyme responsible for processing an important mitochondrial transporter evokes some, but not all of the cases of this disease process. Notably, in some women with hyperemesis, the fetus carries the mutation and evokes the vomiting, while mom is simply a heterozygous carrier. The mutation (L-3-hydroxyacyl-CoA dehydrogenase deficiency – LCHAD) involves an enzyme (carnitine palmitoyltransferase I – CPT I) responsible for synthesizing the protein that acts as key transporter for fatty acids across the mitochondrial membrane. The protein involved is called carnitine.

MADELEINE TREBENSKI

Hello men! I thought this would be a good time to remind you that anything you can do, I can do bleeding. That’s right, whatever it is you did today, I can probably do it while hemorrhaging from the most sensitive part of my body. And I won’t die! Remember that when you’re standing on the train in the morning surrounded by bodies — roughly half of them female bodies. They could be bleeding. Standing and bleeding. Walking and bleeding. Smiling and bleeding.